Racers and fit riders who want Giant's race geometry without Propel's deep tubes.
Giant's lightweight race bike: compact sloping top tube, sharp steering, and a fit that has been a stack/reach reference for a long time. Less aero drama than Propel.
Gravel racers. Caledonia if you want road endurance with some dirt; Aspero-5 if you want the aero gravel version.
Gravel-race Cervelo. Trail mixer, low and fast, built for events rather than touring. Aspero-5 adds aero.
Racers who want a climbing Orbea. Orca Aero is the wind-cheating sibling.
Orbea's lightweight race bike, OMX carbon on high kits, and a fit that is race-low without S5 drama. OMX vs OMR changes weight more than geometry.