Riders who want one Trek race bike now that Émonda is gone. If you liked a low Madone or a light Émonda, this is where both fits land.
Gen 8 Madone folds the Émonda brief into the aero bike: Full System Foil shapes, revised IsoFlow, and a frame roughly 320 g lighter than Gen 7 while holding the older Madone's speed.
Sprinters and fast road riders who picked aero over weight. If you wanted the climbing bike in this era, compare stack/reach against the Émonda instead.
Gen 7 Madone: a pure aero race bike built on Kammtail Virtual Foil tubes with the IsoFlow cutout for rear compliance. It is the fast, heavier half of Trek's race line — Émonda is still the light bike in these years.